Document Type

Article

Abstract

Background:

Fasting serum phosphorus (P) was reported to be inversely related to serum glucose and insulin, while the impact of P ingestion is not well documented. The effect of P intake with or before glucose ingestion on postprandial glucose and insulin statuses was investigated.

Method:

Two cross over experiments using healthy male subjects were conducted. Experiment 1: Overnight fasted subjects (n∈=∈7) randomly received: 500 mg of P tablets, glucose (75 g) solution with placebo or 500 mg of P tablets. Experiment 2: Overnight fasted subjects (n∈=∈8) underwent similar procedures to those of experiment 1, except that placebo or 500 mg P tablets were given 60 min prior to glucose ingestion.

Results:

In both experiments, serum P decreased following glucose ingestion. Co-ingestion of P with glucose improved, at time 60 min, postprandial glucose (P∈< ∈0.05), insulin (P∈< ∈0.05), and insulin sensitivity index (p∈< ∈0.006), while P pre-ingestion failed to exert similar effect.

Conclusion: This study suggests that postprandial glucose and insulin are affected by exogenous P supply, especially when co-ingested with glucose.

Digital Object Identifier (DOI)

https://doi.org/10.1186/s12937-015-0101-5

Rights

© 2015 Khattab et al. Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

APA Citation

Khattab, M., Abi-Rashed, C., Ghattas, H., Hlais, S., & Obeid, O. (2015). Phosphorus ingestion improves oral glucose tolerance of healthy male subjects: a crossover experiment. Nutrition Journal, 14,112.https://doi.org/10.1186/s12937-015-0101-5

Download

Share

COinS