The Study of Stress Measurement and Propagation of Cardiomyocytes with Growth Factor Additions
Start Date
12-4-2024 4:00 PM
Location
CLC Ballroom
Document Type
Presentation
Abstract
The Study of Stress Measurement and Propagation of Cardiomyocytes with Growth Factor Additions
Shannon F. Yost¹, Preston F. Erb², Abigail E. Broom¹, Ethan C. Wilson², Diana S. Ivankovic¹
¹Department of Biology and the Center for Cancer Research, Anderson University, Anderson, SC 29621, United States
²Department of Healthcare Genetics and Genomics and School of Nursing, Clemson University, Clemson, SC 29634, United States
Corresponding author: Dr. Diana Ivankovic, Anderson University Department of Biological Sciences, 316 Boulevard, Anderson, SC, United States, divankovic@andersonuniversity.edu
Abstract
Working with cardiomyocytes has become a multifaceted joint venture in an attempt to yield results in several areas of interest. The primary aim of performing stress tests is to develop realistic, reliable clinical models of cardiomyocyte damage including ischemia and electrolyte imbalances. While many treatment options are available in the form of drug therapy or other assistive interventions, they serve to stabilize patient conditions and treat symptoms. By achieving a basis of cardiomyocyte function and simulating different real-life, clinical situations, it is easier to target and look for curative treatment options.
The primary goal of the propagation study is to examine the effects of select growth hormones on cardiomyocytes at younger stages of maturation in hopes of inducing reliable and controlled regeneration. Modern attempts to replenish cardiomyocyte numbers have primarily focused on stem cell and matured cardiomyocyte transplant therapy, providing little to no significant improvement in cell regeneration succeeding follow-up data collection. By targeting mildly differentiated resident precursor cells, myocytes, the potential for assisting cardiac cells to regenerate is made available.
Innovative techniques and novel results from these conjoined studies of both the stress tests and propagation experiments may allow for the development of new bases of clinical treatment regimens for an array of cardiovascular disease processes.
Keywords
Cardiomyocytes, regeneration, cardiovascular disease, growth factors, contractile stress measurement
The Study of Stress Measurement and Propagation of Cardiomyocytes with Growth Factor Additions
CLC Ballroom
The Study of Stress Measurement and Propagation of Cardiomyocytes with Growth Factor Additions
Shannon F. Yost¹, Preston F. Erb², Abigail E. Broom¹, Ethan C. Wilson², Diana S. Ivankovic¹
¹Department of Biology and the Center for Cancer Research, Anderson University, Anderson, SC 29621, United States
²Department of Healthcare Genetics and Genomics and School of Nursing, Clemson University, Clemson, SC 29634, United States
Corresponding author: Dr. Diana Ivankovic, Anderson University Department of Biological Sciences, 316 Boulevard, Anderson, SC, United States, divankovic@andersonuniversity.edu
Abstract
Working with cardiomyocytes has become a multifaceted joint venture in an attempt to yield results in several areas of interest. The primary aim of performing stress tests is to develop realistic, reliable clinical models of cardiomyocyte damage including ischemia and electrolyte imbalances. While many treatment options are available in the form of drug therapy or other assistive interventions, they serve to stabilize patient conditions and treat symptoms. By achieving a basis of cardiomyocyte function and simulating different real-life, clinical situations, it is easier to target and look for curative treatment options.
The primary goal of the propagation study is to examine the effects of select growth hormones on cardiomyocytes at younger stages of maturation in hopes of inducing reliable and controlled regeneration. Modern attempts to replenish cardiomyocyte numbers have primarily focused on stem cell and matured cardiomyocyte transplant therapy, providing little to no significant improvement in cell regeneration succeeding follow-up data collection. By targeting mildly differentiated resident precursor cells, myocytes, the potential for assisting cardiac cells to regenerate is made available.
Innovative techniques and novel results from these conjoined studies of both the stress tests and propagation experiments may allow for the development of new bases of clinical treatment regimens for an array of cardiovascular disease processes.