2023 - Full Presentation Schedule
Combinatory Effects of microRNA modulation and Viral Oncolysis on Pancreatic ductal adenocarcinoma
Abstract
Pancreatic ductal adenocarcinoma (PDAC) is arguably one of the most lethal and aggressive form of pancreatic cancer, with poor prognosis due to an immunologically cold tumor microenvironment making it difficult. With it being the most common type of pancreatic cancer, it accounts for approximately 90% of cases with an overall 5-year survival rate of 7%-9% worldwide, per the National Cancer Institute.
Exosomes are tiny extracellular vesicles that are secreted by almost all cells, and they carry a diverse range of biomolecules, such as proteins and microRNAs, within their cargo. Dysregulation of microRNA (miR) expression and function has been implicated in various cellular processes, including cancer proliferation. miR-7 has been shown that at physiological levels play a role in suppressing expression in oncogenes that play a role in the processes of PDAC. The downregulation of miR-7 inhibits proliferation, migration, and invasion within PDAC tumor microenvironment. Oncolytic viruses (OV) are naturally existing viruses that can replicate in cancerous cells to lyse tumors without killing healthy cells and has been known to be a significant helpful tool to treat pancreatic cancer.
In this study, we aim to explore the potential therapeutic synergism with a combinatorial approach of restoring miR-7 via exosomes and Oncolytic Herpes Simplex Virus (oHSV) on PDAC cells. Our preliminary findings show enrichment of miR-7 paired with oHSV treatment significantly impacts PDAC cell viability in vitro. Once validated, this approach has the potential to facilitate the development of more effective therapeutic stratification approaches for patients with PDAC.
Combinatory Effects of microRNA modulation and Viral Oncolysis on Pancreatic ductal adenocarcinoma
CASB 104 - Anatomy and Cell and Molecular Biology
Pancreatic ductal adenocarcinoma (PDAC) is arguably one of the most lethal and aggressive form of pancreatic cancer, with poor prognosis due to an immunologically cold tumor microenvironment making it difficult. With it being the most common type of pancreatic cancer, it accounts for approximately 90% of cases with an overall 5-year survival rate of 7%-9% worldwide, per the National Cancer Institute.
Exosomes are tiny extracellular vesicles that are secreted by almost all cells, and they carry a diverse range of biomolecules, such as proteins and microRNAs, within their cargo. Dysregulation of microRNA (miR) expression and function has been implicated in various cellular processes, including cancer proliferation. miR-7 has been shown that at physiological levels play a role in suppressing expression in oncogenes that play a role in the processes of PDAC. The downregulation of miR-7 inhibits proliferation, migration, and invasion within PDAC tumor microenvironment. Oncolytic viruses (OV) are naturally existing viruses that can replicate in cancerous cells to lyse tumors without killing healthy cells and has been known to be a significant helpful tool to treat pancreatic cancer.
In this study, we aim to explore the potential therapeutic synergism with a combinatorial approach of restoring miR-7 via exosomes and Oncolytic Herpes Simplex Virus (oHSV) on PDAC cells. Our preliminary findings show enrichment of miR-7 paired with oHSV treatment significantly impacts PDAC cell viability in vitro. Once validated, this approach has the potential to facilitate the development of more effective therapeutic stratification approaches for patients with PDAC.