UP-05 Comparing the Effects of Pharmacological and Demographic Factors Between Male and Female Patients Diagnosed with Late-Onset and Early-Onset Alzheimer's Disease.

UP-05 Comparing the Effects of Pharmacological and Demographic Factors Between Male and Female Patients Diagnosed with Late-Onset and Early-Onset Alzheimer's Disease.

Objective: The current study investigates differences in men and women patients with Late-onset Alzheimer’s disease (LOAD) and Early-onset Alzheimer’s disease (EOAD)using pharmacological and demographic factors.

Method: Data for this study was collected from the Prisma Health Upstate Alzheimer’s patients registry between 2016-2021. Multivariate analysis was used to predict specific pharmacological and demographic factors associated with men and women with LOAD and EOAD.

Results: A total of 91.7% LOAD and 8.3% EOAD patients were identified. In the adjusted analysis, men AD patients that were administered memantine [OR=1.588, 95% CI, 1.175-2.145, p=0.003], and buspirone [OR = 1.971, 95% CI, 1.221-3.183, p=0.006] were more likely to be associated with EOAD, whereas increasing age [OR = 0.816, 95% CI, 0.799-0.834, p

Conclusion: Our findings identified that specific demographic and pharmacological factors did affect men and women with LOAD and EOAD. These findings suggest the need to develop strategies to eliminate disparity in the care of LOAD or EOAD patients.