Facially Amphiphilic Polyionene Biocidal Polymers Derived From Lithocholic Acid

Author(s)

Mitra S. Ganewatta, University of South CarolinaFollow
Md Anisur Rahman
Louis Mercado
Tinom Shokfai
Alan W. Decho, University of South CarolinaFollow
Theresa M. Reineke, Department of Chemistry, University of Minnesota - Twin Cities, 207 Pleasant Street SE, Minneapolis, MN 55455, USA.
Chuanbing Tang, University of South Carolina - ColumbiaFollow

ORCID iD

Tang: https://orcid.org/0000-0002-0242-8245

Document Type

Article

Abstract

Bacterial infections have become a global issue that requires urgent attention, particularly regarding to emergence of multidrug resistant bacteria. We developed quaternary amine-containing antimicrobial poly(bile acid)s that contain a hydrophobic core of lithocholic acid in the main-chain. Interestingly, by choosing appropriate monomers, these cationic polymers can form core-shell micelles. These polymers exhibited biocidal activity against both Gram-positive and Gram-negative bacterial species. It is demonstrated that the micelles can deliver hydrophobic antibiotics that functionally have dual antimicrobial activities. Cytotoxicity assays against HeLa cells showed dosage-dependent toxicity for polymers with longer linkers.

Digital Object Identifier (DOI)

https://doi.org/10.1016/j.bioactmat.2018.02.001

Publication Info

Published in Bioactive Materials, Volume 3, Issue 2, 2018, pages 186-193.

Rights

© 2018 The Authors. Production and hosting by Elsevier B.V. on behalf of KeAi Communications Co., Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

APA Citation

Ganewatta, M., Rahman, M., Mercado, L., Shokfai, T., Decho, A., Reineke, T., & Tang, C. (2018). Facially amphiphilic polyionene biocidal polymers derived from lithocholic acid. Bioactive Materials, 3(2), 186-193. https://doi.org/10.1016/j.bioactmat.2018.02.001