Date of Award
Fall 2022
Degree Type
Thesis
Department
Biological Sciences
Director of Thesis
Dr. Hexin Chen
Second Reader
Manikanda Raja
Abstract
Doxorubicin (Dox) is a commonly used chemotherapy drug for treating breast cancer. While it is very effective, the main limitation of Dox treatment is subsequent cytotoxicity. Berbamine dihydrochloride (BBM) is a natural benzylisoquinoline alkaloid that is extracted from the plant, Berbaris amurensis. It has been widely used in traditional medicine to treat individuals with inflammatory diseases for many centuries. It has already been shown that combining BBM with Dox synergistically enhances the efficacy of Dox treatment on breast cancer in vitro. To eventually translate these findings into a clinical setting, this study aims to explore this therapeutic potential in vivo using mouse xenograft models, while also exploring possible mechanisms of action initiated by BBM treatment. In this study, we identified that BBM does continue to have a synergistic effect with Dox in vivo. These findings strongly suggest that there is therapeutic potential of using Dox with BBM in breast cancer treatment.
First Page
1
Last Page
30
Recommended Citation
Borglum, Kristina G., "Berbamine Enhances the Efficacy of Doxorubicin Treatment for Breast Cancer In Vitro and In Vivo" (2022). Senior Theses. 724.
https://scholarcommons.sc.edu/senior_theses/724
Rights
© 2022, Kristina G. Borglum
