Date of Award
Spring 2022
Degree Type
Thesis
Department
Biological Sciences
Director of Thesis
Kandy T. Velázquez, Ph.D.
First Reader
Reilly T. Enos, Ph.D.
Second Reader
Reilly T. Enos, Ph.D.
Abstract
Tumor necrosis factor-alpha, an immune cytokine, has demonstrated a significant role in inflammation, which causes cancer over time. However, the effects of TNF-alpha on tumor growth are relatively unknown. Its effects are mediated via TNF receptors p55 and p75, which are expressed in different cells in the body and have slight structural differences. Studies have shown that TNFR-p55 has pro-apoptotic effects, whereas TNFR-p75 transmits survival signals. However, there is limited research available on TNF receptors and colorectal cancer.
This project focuses specifically on TNFR2, or TNFR-p75, and attempts to establish whether TNFR2 inhibition in mice with colitis-induced colorectal cancer promotes tumor growth. Previous research indicates TNFR2 in colorectal cancer tissues plays a role in promoting tumorigenesis; however, the results of this study find that TNFR2 did not play a significant role in tumor growth.
First Page
1
Last Page
20
Recommended Citation
Shametaj, Yvone, "Effects of Tumor Necrosis Factor Receptor p75 on Tumor Burden in a Mouse Model of Colorectal Cancer" (2022). Senior Theses. 503.
https://scholarcommons.sc.edu/senior_theses/503
Rights
© 2022, Yvone Shametaj