Date of Award
Spring 2020
Degree Type
Thesis
Department
Biological Sciences
Director of Thesis
April South
First Reader
Frank Spinale
Second Reader
Frank Spinale
Abstract
I will be exploring the impact of the large protein Titin on heart failure with a preserved ejection fraction (HFpEF). It was hypothesized that myocardial Titin plays a significant role in the progression of HFpEF through isoform, N2BA and N2B, changes. It was hypothesized that an increase in the quantity of N2B Titin, less compliant, and a decrease in N2BA Titin, more compliant, will be observed as HF progresses, contributing to an increase in passive stiffness involved in heart contraction. I will cover a detailed report on the role of Titin in HFpEF and propose research methods to explore further.
First Page
1
Last Page
20
Recommended Citation
Prickett, Mary M., "Potential Role of the Large Protein Titin in the Development of Heart Failure" (2020). Senior Theses. 334.
https://scholarcommons.sc.edu/senior_theses/334
Rights
© 2020, Mary M Prickett
Included in
Cardiovascular Diseases Commons, Cellular and Molecular Physiology Commons, Circulatory and Respiratory Physiology Commons, Medical Biochemistry Commons