An intermolecular Friedel-Crafts alkylation of indole and tertiary allylic alcohols has been developed. The allylic alcohols were synthesized using a two-step procedure, then exposure of these alcohols to diphenyl phosphate facilitated the desired annulation reaction. This reaction tolerated a variety of indole substitutions to yield 1H,2H,3H,4H-pyrido[1,2-a]indoles.
Wakefield, Bryan H.; Barnes, Romie; Brown, Traeannah; Jones, Ashley M.; Knotts, Victoria A.; and Martinetti, Christina
"Intramolecular Friedel-Crafts Addition of Indoles to Tertiary Allylic Alcohols,"
Journal of the South Carolina Academy of Science: Vol. 20:
1, Article 3.
Available at: https://scholarcommons.sc.edu/jscas/vol20/iss1/3