Date of Award

Summer 2024

Document Type

Open Access Thesis

Department

Epidemiology and Biostatistics

First Advisor

Alyssa Clay-Gilmour

Abstract

Background/Objective: B cell malignancies, which comprise a heterogeneous group of cancers affecting B cell at different stages of its maturation, have been shown to share common genetic variants according to family studies and genome-wide association studies. Yet, little evidence exists on the magnitude of this genetic association. Recent studies have focused on the use of polygenic risk scores (PRS) to determine cross-associations between cancers of different types and of those having shared etiology. In this study, we will test the association between known subtype-specific PRSs (subtypes include (Chronic lymphocytic leukemia (CLL), Multiple myeloma (MM), Non-Hodgkin’s lymphoma (NHL), Hodgkin’s lymphoma (HL) and risk of B-cell acute lymphoblastic leukemia(B-ALL). Methods: This case-control study consists of 446 B-cell ALL cases and 3027 controls aged 18-61 years old selected from an ongoing parent study titled “Determining the Influence of Susceptibility Conveying Variants Related to one-Year mortality after BMT” (DISCOVERY-BMT). Multivariable logistic regression will be used to assess the association of each subtype specific PRS with B-cell ALL risk.

Rights

© 2024, Nadine EL Kalach

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