Date of Award

Spring 2022

Document Type

Open Access Thesis

Department

Exercise Science

First Advisor

Mark Sarzynski

Abstract

Cholesterol efflux capacity (CEC) has been associated with cardiovascular disease risk independent of HDL-C levels. However, the effect of regular exercise on CEC is not yet fully understood. Therefore, we examined the effects of exercise training on CEC in the HERITAGE Family Study. In HERITAGE, subjects participated in an endurance training program that consisted of exercise on a cycle ergometer three times per week for 20 weeks. Global and non-ABCA1 CEC were measured at baseline and post-training in 542 subjects via a cell- based radiolabeled CEC assay. Neither global nor non-ABCA1 CEC significantly changed with training in the whole cohort. Changes in HDL-C and apoA-I were weakly, positively correlated with changes in global efflux at a nominal level (p

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