Date of Award
Spring 2022
Document Type
Open Access Thesis
Department
Exercise Science
First Advisor
Mark Sarzynski
Abstract
Cholesterol efflux capacity (CEC) has been associated with cardiovascular disease risk independent of HDL-C levels. However, the effect of regular exercise on CEC is not yet fully understood. Therefore, we examined the effects of exercise training on CEC in the HERITAGE Family Study. In HERITAGE, subjects participated in an endurance training program that consisted of exercise on a cycle ergometer three times per week for 20 weeks. Global and non-ABCA1 CEC were measured at baseline and post-training in 542 subjects via a cell- based radiolabeled CEC assay. Neither global nor non-ABCA1 CEC significantly changed with training in the whole cohort. Changes in HDL-C and apoA-I were weakly, positively correlated with changes in global efflux at a nominal level (p
Rights
© 2022, Joshua Adam Hawkins
Recommended Citation
Hawkins, J. A.(2022). The Effects of Exercise Training on Cholesterol Efflux Capacity in the HERITAGE Family Study. (Master's thesis). Retrieved from https://scholarcommons.sc.edu/etd/6574