Date of Award

Spring 2020

Document Type

Open Access Dissertation

Department

Biomedical Engineering

First Advisor

Tarek Shazly

Abstract

The central function of the vascular system is the transportation and distribution of blood throughout the body. Occurrence of various forms of vascular disease, in which this central function is compromised, is associated with high mortality and morbidity rates. Vascular disease is an active and multifactorial process causing changes in local hemodynamics and blood vessel wall mechanics. The work presented here aims to advance the current knowledge on the role of local geometrical parameters in vascular disease and endovascular intervention modalities. In our first set of studies, we develop a computational framework to understand the role of aortic geometry in abdominal aortic aneurysm wall mechanics, with the purpose of predicting peak wall stress and the risk of rupture. In our next set of studies, we seek to understand possible associations between local hemodynamics and geometric variables in severe carotid artery stenosis (CAS). Using key geometric descriptors of CAS, we formulate stress-based prediction models that can be useful in disease progression risk stratification. In regard to geometric analyses in an endovascular device technology, studies are focused on identifying microstructurefunction relations in drug-coated balloon (DCB) therapy and developing upon current DCB excipient design. The DCB therapy is an emerging intervention procedure with a great scope for improvement, that integrates angioplasty with local drug delivery to restore lumen patency at atherosclerotic lesion sites. Taken together, results from these studies can vi contribute to clinical practices and healthcare market in capacities including disease severity diagnosis, surgical decision making, and endovascular therapy technologies.

Rights

© 2020, Dara Ahmadi Azar

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