Thermoresponsive Nanogels Based on Different Polymeric Moieties for Biomedical Applications

Author(s)

Sobhan Ghaeini-Hesaroeiye, Biomedical Engineering Department, Faculty of Chemical Engineering, Tarbiat Modares University, Tehran 14115, Iran.
Hossein Razmi Bagtash, Biomedical Engineering Department, Faculty of Chemical Engineering, Tarbiat Modares University, Tehran 14115, Iran.
Soheil Boddohi, Biomedical Engineering Department, Faculty of Chemical Engineering, Tarbiat Modares University, Tehran 14115, Iran.
Ebrahim Vasheghani-Farahani, Biomedical Engineering Department, Faculty of Chemical Engineering, Tarbiat Modares University, Tehran 14115, Iran.
Esmaiel Jabbari, Biomimetic Materials and Tissue Engineering Laboratory, Department of Chemical Engineering, University of South Carolina, Columbia, SC 29208, USA.

Document Type

Article

Abstract

Nanogels, or nanostructured hydrogels, are one of the most interesting materials in biomedical engineering. Nanogels are widely used in medical applications, such as in cancer therapy, targeted delivery of proteins, genes and DNAs, and scaffolds in tissue regeneration. One salient feature of nanogels is their tunable responsiveness to external stimuli. In this review, thermosensitive nanogels are discussed, with a focus on moieties in their chemical structure which are responsible for thermosensitivity. These thermosensitive moieties can be classified into four groups, namely, polymers bearing amide groups, ether groups, vinyl ether groups and hydrophilic polymers bearing hydrophobic groups. These novel thermoresponsive nanogels provide effective drug delivery systems and tissue regeneration constructs for treating patients in many clinical applications, such as targeted, sustained and controlled release.

Digital Object Identifier (DOI)

< a href="https://doi.org/10.3390/gels6030020">https://doi.org/10.3390/gels6030020

Publication Info

Gels (Basel, Switzerland), Issue 3, 2020.

Rights

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

APA Citation

Ghaeini-Hesaroeiye, S., Razmi Bagtash, H., Boddohi, S., Vasheghani-Farahani, E., & Jabbari, E. (2020). Thermoresponsive Nanogels Based on Different Polymeric Moieties for Biomedical Applications. Gels, 6(3), 20. https://doi.org/10.3390/gels6030020