Document Type
Article
Abstract
Dystonia-PRKRA (DYT-PRKRA), previously termed dystonia 16 (DYT16), is a movement disorder which currently has very limited treatments available and no cure. To develop effective therapeutic options, it is essential to characterize the underlying pathophysiology and identify potential drug targets. This review summarizes the recent studies that shed light on the molecular mechanisms involved in DYT-PRKRA pathogenesis. PRKRA gene encodes for the protein PACT (Protein Activator of the Protein Kinase R) and individuals with DYT-PRKRA mutations develop early-onset generalized dystonia. While the precise mechanisms linking PRKRA mutations to neuronal etiology of dystonia remain incompletely understood, recent research indicates that such mutations cause dysregulation of signaling pathways involved in cellular stress response as well as in production of antiviral cytokines interferons (IFNs). This review focuses on the effect of DYT-PRKRA mutations on the known cellular functions of PACT.
Digital Object Identifier (DOI)
Publication Info
Published in Dystonia, Volume 4, 2025.
Rights
© 2025 Simon and Patel.
This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
APA Citation
Simon, T. A., & Patel, R. C. (2025). Molecular mechanisms in DYT-PRKRA: Pathways regulated by PKR activator protein PACT. Dystonia, 4, Article 14224.http://dx.doi.org/10.3389/dyst.2025.14224