Closing the Loop: Experimental Validation of AI Predicted Ternary Complexes to Enable Rational Design of CDK8-Targeted Degraders

Author(s)

• Li Zhang
• Jia Zheng
• Rebekah Martin
• Jing Li
• Zachary T. Mack
• Hao Ji
• Eugenia V. Broude Ph.D., University of South CarolinaFollow
• Igor Roninson Ph.D., University of South CarolinaFollow
• Mengqian Chen Ph.D., University of South CarolinaFollow
• Campbell McInnes

Publication Info

2026.

© 2026, Li Zhang, Jia Zheng, Rebekah Martin, Jing Li, Zachary T. Mack, Hao Ji, Eugenia V. Broude, Igor B. Roninson, Mengqian Chen, & Campbell McInnes