[Dermatopharmacokinetic Studies of Liangfu Cream in Mice Skin]
Document Type
Article
Abstract
OBJECTIVE: To study the relationship between deposition content and time of the active ingredients in rat skin, and investigate the dermatopharmacokinetics of Liangfu Cream. METHOD: The contents of paeonol, dictamnine, fraxinellone and glycyrrhetinic acid in rat skin were determined by HPLC. The dermatopharmacokinetics parameters were calculated by DAS software. RESULT: The dermatopharmacokinetics of paeonol and glycyrrhetinic acid were two compartment model, while that of dictamnine and fraxinellone were one compartment model: T(1/2Ka) of four active ingredients were 0.307, 0.112, 0.146, 0.216 h, respectively; T(lag) of them were 0.006, 0.123, 0.136, 0.109 h, respectively; all the Tmax of them was 0.5 h; the Cmax, were 40.163, 1.607, 6.725, 100.553 microg x cm(-3), respectively; the t(1/2beta), were 14.719, 1.262, 0.838, 234.807 h, respectively; the AUC(0-infinity), were 16.987, 2.713, 9.345, 697.000 microg x cm(-3) x h(-1), respectively; and the MRT(0-infinity) were 3.662, 1.67, 1.585, 10.897, respectively. CONCLUSION: The skin pharmacokinetics characteristic of four ingredients in Liangfu cream is lined with the cataplasm long time.
Digital Object Identifier (DOI)
Publication Info
Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica, Volume 35, Issue 17, 2010, pages 2254-2557.
APA Citation
Wang, S., Ou, S., Guan, Y., Wu, D., Chen, L., & Zhu, W. (2010). Dermatopharmacokinetic studies of liangfu cream in mice skin. Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica, 35(17), 2254–2257.https://pubmed.ncbi.nlm.nih.gov/21137331/