Increased Risk of Ischemic Stroke Among Women with Bladder Pain Syndrome/Interstitial Cystitis: A Cohort Study from Taiwan
Document Type
Article
Abstract
AIM: Vascular factors are proposed in the etiology of bladder pain syndrome/interstitial cystitis (BPS/IC). In this study, we investigated the risk of stroke among women following a diagnosis of BPS/IC over 3 years of follow-up, compared to controls without a BPS/IC diagnosis. METHODS: This retrospective cohort study used data retrieved from the Taiwan "Longitudinal Health Insurance Database 2000." We identified 847 women who received a diagnosis of BPS/IC between January 1, 2001 and December 31, 2008 (study group) and 4,235 comparison women (women without a BPS/IC diagnosis matched on age and other selected demographic variables. All subjects were tracked for 3 years following the index date to identify those who received a diagnosis of stroke during follow-up. RESULTS: The stroke incidence rate was 20.86 (95% confidence interval (CI): 15.78-27.07) and 11.65 (95% CI: 9.88-13.64) per 1,000 person-years among the study and comparison cohorts, respectively. Cox regression analysis showed a stroke hazard ratio (HR) of 1.52 (95% CI: 1.09-2.14) in the BPS/IC group relative to the comparison group over 3-year follow-up, after adjusting for hypertension, diabetes, coronary heart disease, atrial fibrillation, hyperlipidemia, and chronic kidney disease. The adjusted HR of ischemic stroke was 1.52 (95% CI: 1.02-2.27). However, there was no significant difference between the two groups in hemorrhagic stroke risk. CONCLUSIONS: Our study demonstrates an association between BPS/IC and a subsequent ischemic stroke diagnosis among women in Taiwan.
Digital Object Identifier (DOI)
Publication Info
Published in Neurourology and Urodynamics, Volume 34, Issue 1, 2013, pages 44-49.
APA Citation
Chung, S.-D., Xirasagar, S., Lin, C.-C., Ling, W., Li, H.-C., & Lin, H.-C. (2013). Increased risk of ischemic stroke among women with bladder pain syndrome/interstitial cystitis: A cohort study from Taiwan. Neurourology and Urodynamics, 34(1), 44–49. https://doi.org/10.1002/nau.22515
Rights
© 2013 Wiley Periodicals, Inc.