https://doi.org/10.1016/j.smhs.2021.08.004

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ORCID iD

10.1016/j.smhs.2021.08.004

Document Type

Article

Abstract

Non-steroidal anti-inflammatory drugs' anti-pyretic and anti-inflammatory effects has led some individuals to theorize these medications may blunt core body temperature (Tc) increases during exercise. We utilized a double-blind, randomized, and counterbalanced cross-over design to examine the effects of a 24-h naproxen dose (3-220 mg naproxen pills) and placebo (0 mg naproxen) on Tc and plasma interleukin-6 (IL-6) concentrations during cycling in a hot or ambient environment. Participants ( = 11; 6 male, 5 female; age = 27.8 ± 6.5 years, weight = 79.1 ± 17.9 kg, height = 177 ± 9.5 cm) completed 4 conditions: 1) placebo and ambient (Control); 2) placebo and heat (Heat); 3) naproxen and ambient (Npx); and 4) naproxen and heat (NpxHeat). Dependent measures were taken before, during, and immediately after 90 min of cycling and then 3 h after cycling. Overall, Tc significantly increased pre- (37.1 ± 0.4 °C) to post-cycling (38.2 ± 0.3 °C, = 150.5, < 0.001) and decreased during rest (37.0 ± 0.3 °C, = 201.6, < 0.001). Rate of change or maximum Tc were not significantly different between conditions. IL-6 increased pre- (0.54 ± 0.06 pg/ml) to post-exercise (2.46 ± 0.28 pg/ml, < 0.001) and remained significantly higher than pre-at 3 h post- (1.17 ± 0.14 pg/ml, 95% = -1.01 to -0.23, = 0.001). No significant IL-6 differences occurred between conditions. A 24-h, over-the-counter naproxen dose did not significantly affect Tc or IL-6 among males and females cycling in hot or ambient environments.

Digital Object Identifier (DOI)

https://doi.org/10.1016/j.smhs.2021.08.004

APA Citation

Emerson, D. M., Chen, S. C., Torres-McGehee, T. M., Pfeifer, C. E., Emerson, C. C., & Davis, J. M. (2021). An acute naproxen dose does not affect core temperature or Interleukin-6 during cycling in a hot environment. Sports Medicine and Health Science, 3(4), 243–251. https://doi.org/10.1016/j.smhs.2021.08.004

Rights

© 2021 The Authors. This is an open access article under the CC BY-NC-ND license.

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