Document Type


Subject Area(s)

Adult; Anti-Bacterial Agents (pharmacology, therapeutic use); Case-Control Studies; Female; Humans; Male; Middle Aged; Retrospective Studies; Trimethoprim, Sulfamethoxazole Drug Combination (pharmacology); Urinary Tract Infections (drug therapy, epidemiology)


OBJECTIVES: This study aimed to predict trimethoprim/sulfamethoxazole (SXT) resistance in patients with community-onset urinary tract infection (UTI) due to Enterobacteriaceae based on patient-specific risk factors. METHODS: This was a retrospective case-control study in Prisma Health facilities in central South Carolina, USA, including three community hospitals, affiliated emergency departments and ambulatory clinics, including adult patients with community-onset UTI due to Enterobacteriaceae (1 April 2015 to 29 February 2016). Multivariate logistic regression was used to examine risk factors for SXT resistance. RESULTS: Among 351 unique patients with community-onset UTI, 71 (20.2%) had SXT-resistant Enterobacteriaceae urinary isolates. Overall, median age was 64 years and 252 (71.8%) were female. A multivariate model identified prior urinary infection/colonisation with SXT-resistant Enterobacteriaceae (OR=8.58, 95% CI 3.92-18.81; P

Digital Object Identifier (DOI)

Rights 2213-7165/© 2019 International Society for Antimicrobial Chemotherapy. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://

APA Citation

DeMarsh, M., Bookstaver, P., Gordon, C., Lim, J., Griffith, N., & Bookstaver, N. et al. (2020). Prediction of trimethoprim/sulfamethoxazole resistance in community-onset urinary tract infections. Journal Of Global Antimicrobial Resistance, 21, 218-222.