The role of the endoplasmic reticulum (ER) has evolved from protein synthesis, processing, and other secretory pathways to forming a foundation for lipid biosynthesis and other metabolic functions. Maintaining ER homeostasis is essential for normal cellular function and survival. An imbalance in the ER implied stressful conditions such as metabolic distress, which activates a protective process called unfolded protein response (UPR). This response is activated through some canonical branches of ER stress, i.e., the protein kinase RNA-like endoplasmic reticulum kinase (PERK), inositol-requiring enzyme 1α (IRE1α), and activating transcription factor 6 (ATF6). Therefore, chronic hyperglycemia, hyperinsulinemia, increased proinflammatory cytokines, and free fatty acids (FFAs) found in diabesity (a pathophysiological link between obesity and diabetes) could lead to ER stress. However, limited data exist regarding ER stress and its association with diabesity, particularly the implicated proteins and molecular mechanisms. Thus, this review highlights the role of ER stress in relation to some proteins involved in diabesity pathogenesis and provides insight into possible pathways that could serve as novel targets for therapeutic intervention.
Digital Object Identifier (DOI)
Published in Oxidative Medicine and Cellular Longevity, Volume 2021, 2021.
© 2021 Sagir Mustapha et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Mustapha, S., Mohammed, M., Azemi, A. K., Yunusa, I., Shehu, A., Mustapha, L., Wada, Y., Ahmad, M. H., Ahmad, W. A., Rasool, A. H., & Mokhtar, S. S. (2021). Potential roles of endoplasmic reticulum stress and cellular proteins implicated in diabesity. Oxidative Medicine and Cellular Longevity, 2021, 1–18. https://doi.org/10.1155/2021/8830880