Date of Award

Spring 2020

Document Type

Open Access Dissertation

Department

Chemistry and Biochemistry

First Advisor

Chuanbing Tang

Abstract

In this thesis, multicyclic natural products and metallocene-containing polymers were synthesized for biomedical applications.

Chapter 1 describes the overall background, the recent development of natural product-based antimicrobial biomaterial and metallocene containing polymer for biomedical application. Afterward, the primary research objectives of my research are illustrated.

In chapter 2, a multicyclic natural product derived guanidine-based facially amphiphilic homopolymers and copolymers were synthesized. Cholic acid is one of the bile acid derivatives used to prepare facially amphiphilic moieties. A neutral polyethylene glycol (PEG) component was used to prepare copolymers with cholic acid. Reversible-addition fragmentation chain transfer (RAFT) polymerization technique was used to prepare all the polymers. The self-assembly of all polymers was also investigated. Finally, the hemolysis activity of guanidine-based facial amphiphilic polymers was measured against red blood cells.

The synthesis of metal-containing copolymers was illustrated in chapter 3. The diblock copolymers were prepared from cationic cobaltocenium and neutral PEG moieties. PEG-based macro raft agent was used to make cobaltocenium containing diblock copolymer. These diblock block copolymers can be a good candidate for biomedical applications, especially for gene delivery.

Finally, a summary and future directions of this dissertation research are provided in chapter 4. In future work, some suggestions about developing new molecular biomass with true facial amphiphilicity for antimicrobial application and metallocene based polymers for gene delivery are given.

Available for download on Wednesday, May 05, 2021

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