Organic Chemistry, Biomolecular Chemistry
Cyanamide was introduced into the rhodamine spirolactam framework to produce a colorless and non-fluorescent compound RBCN. It shows a reversible ring-opening/ring-closure process in response to the solution pH, which exhibits an “ON/OFF” switching in its fluorescence. Different from other rhodamine-type dyes, the ring-open form of RBCN is stable in protic solvents under neutral, near neutral and basic conditions, showing a pink color and very strong fluorescence. We also demonstrated the potential of RBCN in live cell imaging.
Published in Organic & Biomolecular Chemistry, Volume 11, Issue 11, 2013, pages 1805-1809.
© Organic & Biomolecular Chemistry 2013, Royal Society of Chemistry
Li, H., Guan, H., Duan, X., Hu, J., Wang, G., & Wang, Q. (2013). An acid catalyzed reversible ring-opening/ring-closure reaction involving a cyano-rhodamine spirolactam. Organic & Biomolecular Chemistry, 11(11), 1805-1809.