ORCID iD
Chuanbing Tang: https://orcid.org/0000-0002-0242-8241
Document Type
Article
Abstract
Bacterial infections and antibiotic resistance, particularly by Gram-negative pathogens, have become a global healthcare crisis. We report the design of a class of cationic antimicrobial polymers that cluster local facial amphiphilicity from repeating units to enhance interactions with bacterial membranes without requiring a globally conformational arrangement associated with highly unfavorable entropic loss. This concept of macromolecular architectures is demonstrated with a series of multicyclic natural product-based cationic polymers. We have shown that cholic acid derivatives with three charged head groups are more potent and selective than lithocholic and deoxycholic counterparts, particularly against Gram-negative bacteria. This is ascribed to the formation of true facial amphiphilicity with hydrophilic ion groups oriented on one face and hydrophobic multicyclic hydrocarbon structures on the opposite face. Such local facial amphiphilicity is clustered via a flexible macromolecular backbone in a concerted way when in contact with bacterial membranes.
Digital Object Identifier (DOI)
Publication Info
Published in Nature Communications, Volume 9, Issue 5231, 2018, pages 1-10.
This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/ licenses/by/4.0/.
Rahman, M., Bam, M., Luat, E., Jui, M., Ganewatta, M., & Shokfai, T. et al. (2018). Macromolecular-clustered facial amphiphilic antimicrobials. Nature Communications, 9(1). https://doi.org/10.1038/s41467-018-07651-7
APA Citation
Rahman, M., Bam, M., Luat, E., Jui, M., Ganewatta, M., & Shokfai, T. et al. (2018). Macromolecular-clustered facial amphiphilic antimicrobials. Nature Communications, 9(1). https://doi.org/10.1038/s41467-018-07651-7
Rights
This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/ licenses/by/4.0/.
Rahman, M., Bam, M., Luat, E., Jui, M., Ganewatta, M., & Shokfai, T. et al. (2018). Macromolecular-clustered facial amphiphilic antimicrobials. Nature Communications, 9(1). https://doi.org/10.1038/s41467-018-07651-7