Date of Award
Fall 2025
Document Type
Open Access Thesis
Department
Biomedical Science
First Advisor
Frank Spinale
Abstract
Fibroblast activation protein (FAP) is abundantly expressed in cancer associated fibroblasts and contributes to extracellular matrix (ECM) remodeling. Recent studies using imaging techniques have identified increased levels of FAP in the left ventricle (LV) of patients identified as at risk for developing heart failure. However, the role of FAP in regulated LV myocardial structure and function remains unclear. This project tested two hypotheses: First, genetic ablation of FAP would modify LV structure and function and be more pronounced with aging. Second, genetic ablation of FAP would modify LV structure and function with LV pressure overload (LVPO) accompanied by ECM remodeling.
Rights
© 2025, Amelia Marie Churillo
Recommended Citation
Churillo, A. M.(2025). The Role of Fibroblast Activation Protein on Left Ventricular Growth and Extracellular Matrix Remodeling as a Function of Age and Pressure Overload. (Master's thesis). Retrieved from https://scholarcommons.sc.edu/etd/8697