Rapid Classification of a Protein Fold Family Using a Statistical Analysis of Dipolar Couplings

Author(s)

Homayoun Valafar, University of South Carolina - ColumbiaFollow
James H. Prestegard

Document Type

Article

Abstract

Motivation: One of the primary aims of the structural genomics initiative is the determination of representative structures from each protein fold family. Given this objective, it is important to rapidly identify proteins that belong to a family that is already well populated (so they can be eliminated from further studies), or more importantly identify proteins that represent new families of fold.

Results: A method for rapid classification to a fold family by the statistical analyses of unassigned the ¹⁵N–¹H residual dipolar couplings is presented. The required NMR data can be quickly acquired and analyzed. Using this method, structure determination efforts can be focused on more unique and interesting structures, and the overall efficiency in the construction of an information-rich library can be increased.

Publication Info

Published in Bioinformatics, Volume 19, Issue 12, 2003, pages 1549-1555.

Rights

Copyright Oxford Journals, 2003.

H. Valafar, Presetegard J., (2003). Rapid Classification of a Protein Fold Family Using a Statistical Analysis of Dipolar Couplings. Bioinformatics, 19(12):1549-55. http://dx.doi.org/10.1093/bioinformatics/btg201