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Caravel Undergraduate Research Journal

Abstract

Regular physical activity is a recommended strategy to prevent obesity via increasing fatty acid metabolism. AMP-activated protein kinase (AMPK) has been associated with the activation of lipolysis in adipose tissue. Furthermore, it has been demonstrated that a single bout of exercise increases AMPK activity in adipocytes; however, the mechanism by which AMPK regulates exercise-induced adipocyte metabolism has yet to be determined. To examine the role of AMPK in exercise-induced adipocyte metabolism, we utilized fat-specific AMPK alpha 1 and alpha 2 knockout mice (FKO). Wild type (WT) and FKO mice were divided into sedentary (Sed) and exercise (EX) groups. After 6 weeks of exercise training, there was no difference in body weight or food intake between the two groups. However, FKO mice showed significantly increased lean body composition (86.90% vs.83.89%) and decreased fat composition (13.10% vs. 16.21%) compared to WT (p

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