ORCID Identifier

Marcos-Gragera, Rafael

0000-0001-9824-3657

Perez-Gomez, Beatriz

0000-0002-4299-8214

Aragones, Nuria

0000-0003-0983-2156

0000-0002-1308-9927

Lozano-Lorca, Macarena

0000-0001-5282-814X

Shivappa, Nitin

0000-0003-0441-8896

Molina-Barcelo, Ana

0000-0001-5113-6475

Huerta, Jose Maria

0000-0002-9637-3869

Castano-Vinyals, Gemma

0000-0003-4468-1816

Martin, Vicente

0000-0003-0552-2804

Document Type

Article

Abstract

Inflammation and antioxidant capacity have been associated with colorectal and breast cancer. We computed the dietary inflammatory index (DII®), and the total dietary non-enzymatic antioxidant capacity (NEAC) and associated them with colorectal and breast cancer risk in the population-based multi case-control study in Spain (MCC-Spain). We included 1852 colorectal cancer and 1567 breast cancer cases, and 3447 and 1486 population controls, respectively. DII score and NEAC were derived using data from a semi-quantitative validated food frequency questionnaire. Unconditional logistic regression models were used to estimate odds ratios (OR) and 95% confidence intervals (95%CI) for energy-adjusted DII (E-DII), and a score combining E-DII and NEAC. E-DII was associated with colorectal cancer risk (OR = 1.93, highest quartile versus lowest, 95%CI:1.60–2.32; p-trend:0.10). The combined score of high E-DII scores and low antioxidant values were associated with colorectal cancer risk (OR = 1.48, highest quartile versus lowest, 95%CI: 1.26–1.74; p-trend:

Digital Object Identifier (DOI)

10.3390/nu11061406

APA Citation

Obón-Santacana, Romaguera, Gracia-Lavedan, Molinuevo, Molina-Montes, Shivappa, Hebert, Tardón, Castaño-Vinyals, Moratalla, Guinó, Marcos-Gragera, Azpiri, Gil, Olmedo-Requena, Lozano-Lorca, Alguacil, Fernández-Villa, Martín, … Amiano. (2019). Dietary Inflammatory Index, Dietary Non-Enzymatic Antioxidant Capacity, and Colorectal and Breast Cancer Risk (MCC-Spain Study). Nutrients, 11(6), 1406.

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