Studies showing an increase in plasma concentration of high density lipoprotein cholesterol (HDL-C) with moderate exercise have usually rejected the role of body weight change in the HDL-C raising process, ostensibly because the amount of weight lost has been negligible. To investigate HDL-C changes more thoroughly, we followed initially sedentary middle-aged men randomly assigned to either a moderate running (N=36) or a sedentary control (N=28) group for one year. Among runners, one-year changes in plasma HDL-C concentrations correlated strongly with their body weight changes (r = -0.53, P < 0.001). Curve-fitting procedures and regression analysis suggested that processes associated with weight change produce much of the plasma HDL-C changes induced by moderate exercise and that changes in HDL-C concentration predominantly reflect changes in the reputedly anti-atherogenic HDL2 sub-component. Further, the interaction between weight change and plasma HDL-C concentration was significantly different (P
Postprint version. Published in Atherosclerosis, Volume 47, Issue 2, 1983, pages 173-185.
Williams, P. T., Wood, P. D., Krauss, R. M., Haskell, W. L., Vranizan, K. M., Blair, S. N., ... Farquhar, J. W. (1983). Does weight loss cause the exercise-induced increase in plasma high density lipoproteins? Atherosclerosis, 47(2), 173-185.
© Atherosclerosis, 1983, Elsevier
NOTICE: This is the author's version of a work that was accepted for publication in Atherosclerosis. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Atherosclerosis, [Volume #47, Issue #2, (1983)].