PY-06 The Effects of Adenosine on Temporal Perception
Start Date
31-3-2023 10:30 AM
End Date
31-3-2023 12:30 PM
Document Type
Poster
Abstract
Time perception plays a crucial role in many daily tasks. This cognitive process is used for walking, eating, and many forms of communication. Certain neuromodulators and neurotransmitters have been shown to alter this physiological process.
Our lab previously tested and determined that caffeine speeds up temporal perception by acting as an adenosine antagonist. The reverse effect was the focus of our most recent experiment, which focused on adenosine and its potential to slow down time perception. Adenosine, an inhibitory neurotransmitter, plays an important role in depressing the nervous system and can increase the pressure for sleep.
This study tested whether various doses of adenosine would alter time perception by slowing it down. Twenty four female Wistar rats were trained in an operant chamber using the Stubbs Procedure to discriminate between long (x > 4 seconds) and short intervals (x < 4 seconds). After this discrimination was learned, adenosine (2.5, 5, 7.5, or 10 mg/kg) or a sham control was injected intraperitoneally 15 minutes prior to beginning the timing procedure using a counterbalanced, within-subjects design.
No statistically significant slowing down of temporal perception was observed although one condition did approach significance (t(23) = 1.323, p = 0.099). In addition, no effect was observed on overall accuracy after adenosine injection.
PY-06 The Effects of Adenosine on Temporal Perception
Time perception plays a crucial role in many daily tasks. This cognitive process is used for walking, eating, and many forms of communication. Certain neuromodulators and neurotransmitters have been shown to alter this physiological process.
Our lab previously tested and determined that caffeine speeds up temporal perception by acting as an adenosine antagonist. The reverse effect was the focus of our most recent experiment, which focused on adenosine and its potential to slow down time perception. Adenosine, an inhibitory neurotransmitter, plays an important role in depressing the nervous system and can increase the pressure for sleep.
This study tested whether various doses of adenosine would alter time perception by slowing it down. Twenty four female Wistar rats were trained in an operant chamber using the Stubbs Procedure to discriminate between long (x > 4 seconds) and short intervals (x < 4 seconds). After this discrimination was learned, adenosine (2.5, 5, 7.5, or 10 mg/kg) or a sham control was injected intraperitoneally 15 minutes prior to beginning the timing procedure using a counterbalanced, within-subjects design.
No statistically significant slowing down of temporal perception was observed although one condition did approach significance (t(23) = 1.323, p = 0.099). In addition, no effect was observed on overall accuracy after adenosine injection.