Phidianidines are a class of compound that has been extracted from the sea mollusk Phidianis militaris. These compounds have been shown to exhibit a variety of useful properties such as antihistamine effects, anti-cancer activity, agonism of the µ-opioid receptor and neuroprotection. The biological activities are thought to be caused by the 1,2,4- oxadiazole ring found within the molecule. The goal of this project is to synthesize analogues of phidianidine that contain a 1,2,3-triazole instead of the 1,2,4 oxadiazole ring using a method that will allow for other regions of the molecule to be changed. This will help to elucidate the role of the 1,2,4-oxadiazole ring in biological activity as well as probe if the 1,2,3-triazole analogue can provide significant improvement to any activities.
Laws, David III; King, Dillon; and Wakefield, Bryan H.
"Progress toward phidianidine analogues containing a 1,2,3-triazole ring,"
Journal of the South Carolina Academy of Science: Vol. 15
, Article 3.
Available at: https://scholarcommons.sc.edu/jscas/vol15/iss2/3