Jessica A. Silva-Conejo Katrina McCarter Tessa Greene Joshua V. Ruppel
University of South Carolina - Upstate
Photodynamic Therapy (PDT) uses photosensitizers that are activated by light to produce singlet oxygen that can cause cell damage and potential cell death. Phthalocyanines are promising photosensitize..
Photodynamic Therapy (PDT) uses photosensitizers that are activated by light to produce singlet oxygen that can cause cell damage and potential cell death. Phthalocyanines are promising photosensitizers due to their absorption at clinically relevant wavelengths, meaning that they absorb at a wavelength that can penetrate deeper into tissues. One challenge with using Phthalocyanines is that they have very low solubility in biological media. One potential approach to increase solubility is through glycoconjugation. Glycoconjugation can also be used as a strategy to increase selectivity toward targeted tissues. Glycoconjugated phthalocyanines can be synthesized using a copper catalyzed azide-alkyne cycloaddition reaction, otherwise known as a “click reaction.” Moreover, zinc glycoconjugated phthalocyanines are of interest due to their efficiency in generating singlet oxygen. We will present our efforts towards the synthesis of zinc glycoconjugated phthalocyanines displaying different symmetries such as the so called A4 and A3B phthalocyanines.