University of South Carolina School of Medicine Greenville Wake Forest University
Exploring Drug Efficacy in the Pediatric Population: Determining the Differences Among Various Drug Classes William F. Gardner II1, M. Jacob Wurst1, Brooks McPhail, PhD1,2 1University of South Carolin..
Exploring Drug Efficacy in the Pediatric Population: Determining the Differences Among Various Drug Classes William F. Gardner II1, M. Jacob Wurst1, Brooks McPhail, PhD1,2 1University of South Carolina School of Medicine Greenville, Greenville, SC, 2Cincinnati Children's Hospital Medical Center, Cincinnati, OH Introduction: Pharmacodynamics is commonly defined as what the drug does to the body. The pharmacodynamic effects of a drug are required to determine its efficacy and safety. Due to the unique nature of pediatric development, and the challenges in doing research on children, the efficacy and safety of many drugs are not well defined in the pediatric population. Methods: Over 60 scientific research articles were evaluated to assess the safety and efficacy of drugs in children. The pediatric data that were obtained included age, body weight, race, dosing, adverse effects, efficacy, and safety. Antibiotics, analgesics, anti-inflammatory, and chemotherapy medications were compiled to evaluate the usage and activity of each drug during development. Results: Data suggests that the administration of anti-inflammatory and analgesic drugs both increased with age. Antiviral and anti-cancer drugs both had a consistent number studied across age groups, while limited studies were available for anti-fungal and anti-malarial drugs (1 study each). Of the drugs studied, the administration of sulfadoxine-pyrimethamine, anti-thymocyte globulin (ATG), and esomeprazole were the only ones where the doses tested did not result in adequate treatment in children. Conclusion: Limited studies are available regarding the pharmacodynamics of drugs in children throughout development. The current study suggests that the administration of various drugs may change with age. However, several studies that are available obtained their pediatric pharmacodynamic data from computer simulations. The lack of pediatric pharmacodynamic data for many drugs may produce gaps in knowledge that could impact the clinical care of children.