Date of Award

Fall 2019

Document Type

Open Access Dissertation

Department

Chemistry and Biochemistry

First Advisor

Esmaiel Jabbari

Second Advisor

Thomas Makris

Abstract

This thesis spots the light on the development of a novel multi-functionalized system for application in tissue engineering and on-demand morphogens delivery. Three types of materials used in this study are synthetic polymer, biopolymer, and nanomaterials. Polyethylene glycol (PEG), a synthetic polymer was chosen in this study because of its high biocompatibility, non-immunogenicity, inert nature, ease of modification, and reduces protein denaturation to provide a wide range of physical and mechanical properties. Here, PEG is used one time as a hydrogel, linear polyethylene glycol-co-lactide (LPELA), and another time as peptide-PEG based nanoparticles (PxSPCP). Gelatin, a natural polymer has been widely used for several biomedical applications because of their suitable biocompatibility, tunable physical characteristics, closely mimic some essential properties of the native extracellular matrix (ECM) due to the presence of cell attaching and matrix metalloproteinase responsive peptide motifs. Meanwhile, the peptide-PEG based nanoparticles were included to provide hybrid hydrogel systems to form networks with desired combined properties and characteristics for specific biological applications. These properties could promote cell response to release certains growth factors that induce signaling pathways for cells differentiation. Hence, in this thesis, our goal was to integrate this multifunctional system to develop an ideal type of biomaterials that can letherage the tissue engineering and targeted morphogens delivery for various treatment applications.

Rights

© 2019, Safaa I. Kader

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