Structures of Asymmetric Complexes of Human Neuron Specific Enolase with Resolved Substrate and Product and an Analogous Complex with Two Inhibitors Indicate Subunit Interaction and Inhibitor Cooperativity, Jie Qin, Geqing Chai, John M. Brewer, Leslie L. Lovelace, Lukasz Lebioda
Faculty Publications

Mechanism of N¹⁰-Formyltetrahydrofolate Synthetase Derived from Complexes with Intermediates and Inhibitors, Lesa R. Celeste, Geqing Chai, Magdalena Bielak, Wladek Minor, Leslie L. Lovelace, Lukasz Lebioda
Faculty Publications

Amphitrite ornata Dehaloperoxidase (DHP): Investigations of Structural Factors That Influence the Mechanism of Halophenol Dehalogenation Using “Peroxidase-like” Myoglobin Mutants and “Myoglobin-like” DHP Mutants, Jing Du, Xiao Huang, Shengfang Sun, Chunxue Wang, Lukasz Lebioda, John H. Dawson
Faculty Publications

Structure of Human C8 Protein Provides Mechanistic Insight into Membrane Pore Formation by Complement, Leslie L. Lovelace, Christopher L. Cooper, James M. Sodetz, Lukasz Lebioda
Faculty Publications

Human Thymidylate Synthase with Loop 181–197 Stabilized in an Inactive Conformation: Ligand Interactions, Phosphorylation, and Inhibition Profiles, Beibei Luo, Jayanthi Repalli, Al‐Motassem Yousef, Saphronia R. Johnson, Lukasz Lebioda, Sondra H. Berger
Faculty Publications

Replacement of Val3 in Human Thymidylate Synthase Affects Its Kinetic Properties and Intracellular Stability, Xiao Huang, Lydia M. Gibson, Brittnaie J. Bell, Leslie L. Lovelace, Maria M. Peña, Franklin G. Berger, Sondra H. Berger, Lukasz Lebioda
Faculty Publications

Variants of Human Thymidylate Synthase with Loop 181–197 Stabilized in the Inactive Conformation, Leslie L. Lovelace, Saphronia R. Johnson, Lydia M. Gibson, Brittnaie J. Bell, Sondra H. Berger, Lukasz Lebioda
Faculty Publications

Data Mining of Metal Ion Environments Present in Protein Structures, Heping Zhenga, Maksymilian Chruszcz, Piotr Lasota, Lukasz Lebioda, Wladek Minor
Faculty Publications

The R163K Mutant of Human Thymidylate Synthase Is Stabilized in an Active Conformation: Structural Asymmetry and Reactivity of Cysteine 195, Lydia M. Gibson, Leslie L. Lovelace, Lukasz Lebioda
Faculty Publications

Structural Features of the Ligand Binding Site on Human Complement Protein C8γ: A Member of the Lipocalin Family, Brian Chiswell, Leslie L. Lovelace, Charity Brannen, Eric A. Ortlund, Lukasz Lebioda, James M. Sodetz
Faculty Publications

Cooperative Inhibition of Human Thymidylate Synthase by Mixtures of Active Site Binding and Allosteric Inhibitors, Leslie L. Lovelace, Lydia M. Gibson, Lukasz Lebioda
Faculty Publications

Structures of Thiolate- and Carboxylate-Ligated Ferric H93G Myoglobin:  Models for Cytochrome P450 and for Oxyanion-Bound Heme Proteins, Jie Qin, Roshan Perera, Leslie L. Lovelace, John H. Dawson, Lukasz Lebioda
Faculty Publications

Fluoride Inhibition of Enolase: Crystal Structure and Thermodynamics, Jie Qin, Geqing Chai, John M. Brewer, Leslie L. Lovelace, Lukasz Lebioda
Faculty Publications

Effects of Ligand Binding and Conformational Switching on Intracellular Stability of Human Thymidylate Synthase, Sondra H. Berger, Franklin G. Berger, Lukasz Lebioda
Faculty Publications