The functional magnetic resonance imaging (fMRI) data and brain network analysis have been widely applied to automated diagnosis of neural diseases or brain diseases. The fMRI time series data not only contains specific numerical information, but also involves rich dynamic temporal information, those previous graph theory approaches focus on local topology structure and lose contextual information and global fluctuation information. Here, we propose a novel multi-scale functional connectivity for identifying the brain disease via fMRI data. We calculate the discrete probability distribution of co-activity between different brain regions with various intervals. Also, we consider nonsynchronous information under different time dimensions, for analyzing the contextual information in the fMRI data. Therefore, our proposed method can be applied to more disease diagnosis and other fMRI data, particularly automated diagnosis of neural diseases or brain diseases. Finally, we adopt Support Vector Machine (SVM) on our proposed time-series features, which can be applied to do the brain disease classification and even deal with all time-series data. Experimental results verify the effectiveness of our proposed method compared with other outstanding approaches on Alzheimer’s Disease Neuroimaging Initiative (ADNI) dataset and Major Depressive Disorder (MDD) dataset. Therefore, we provide an efficient system via a novel perspective to study brain networks.
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Published in Frontiers in Neuroscience, Volume 13, 2019, pages 197-.
© 2019 Zhang, Xu, Tang, Zou and Guo. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Zhang, Z., Xu, J., Tang, J., Zou, Q., & Guo, F. (2019). Diagnosis of Brain Diseases via Multi-Scale Time-Series Model. Frontiers in Neuroscience, 13, 197.