Date of Award

1-1-2009

Document Type

Campus Access Thesis

Department

Biomedical Engineering

First Advisor

Esmaiel Jabbari

Abstract

In this Master of Science project, a novel technique of producing aligned nanofibers has been created by using new designed apparatus. Solution electrospinning has been used for nanofibers fabrication. During solution electrospinning, when two negative (-20kV) charged wheels and a positive (+20kV) charged needle were placed in the system, aligned nanofibers were collected on the grounded aluminum collector which was located between two wheels. Polymer solutions were pumped to the system at 1.0 ml/h. As polymer, poly(lactic-co-glycolic acid) (PLGA 50/50) was dissolved in hexafluoro-2-propanol (TCI). Collected nanofibers were examined under Scanning Electron Microscope (SEM). Nanofibers were 0.7 µm in diameter and 1.5 cm in length. Besides creating aligned nanofibers by using a new designed apparatus, the other aim of this project is producing three-dimensional nanofiber structures.

The reason of producing three dimensional nanofibers structure is biomimicking the structure to natural three dimensional bone structure. Furthermore, in order to make three-dimensional nanofiber structure, the collector was turned 90o after a unit time, and nanofiber arrays were printed perpendicularly on top of each other. In addition, the effects of polymer solution viscosity and applied electrical charge to the nanofibers fabrication were also evaluated.

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